Demonstration of praliciguat synergy with nitric oxide in an sGC activity assay
A binding assay to evaluate sGC stimulators
Deborah Dodge, senior scientist at Cyclerion, explains an assay we developed to analyze the binding of Cyclerion’s sGC stimulator praliciguat to sGC. The assay showed that praliciguat binds to sGC with high affinity and requires the presence of nitric oxide, reinforcing our understanding about how praliciguat works. The assay may also further the field of sGC research as it allows scientists to better understand the binding properties of different sGC stimulators.