CY6463 (FORMERLY IW-6463)

Leveraging Biomarker Data & Preclinical Models to Guide the Design of Clinical Studies

Annual Biomarkers in Alzheimer’s Disease Summit (2020)

Christopher Winrow, PhD

This presentation details the application of translational biomarkers to guide clinical activities for IW-6463, a central nervous system-penetrant sGC stimulator. In preclinical studies, IW-6463 has demonstrated beneficial effects across four domains relevant to neurodegenerative diseases: cerebral blood flow, cellular bioenergetics, neuro-inflammation, and neuronal function.

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