Praliciguat treatment induced a marked and sustained decrease in mean arterial pressure in a rat model of hypertension
Mean arterial pressure in Dahl salt-sensitive rats fed either a normal diet or a high-salt diet. Rats fed a high-salt diet were either untreated or treated with praliciguat (1, 3, and 10 mg/kg in chow), or losartan (30 mg/kg, in drinking water). Data are shown as mean+SEM (mmHg); n=8 per group. Tobin et al. J Pharmacol Exp Ther 2018;365:664-675. Copyright © 2018 The Author(s).