The Brain Penetrant Soluble Guanylate Cyclase Stimulator IWP-247 Improved Thigmotaxis and Increased Hippocampal N-acetylaspartate (NAA) Concentrations in Aged Rats
Society for Neuroscience Annual Meeting (2018)
This research describes the effects of IW-6463, a central nervous system-penetrant sGC stimulator, on neurometabolites and learning in aged rats.
IW-6463 improved learning and memory in aged rats
Healthy aged male rats were administered IW-6463 (10 mg/kg, oral) daily during Morris Water Maze training. On days 4 and 5, IW-6463-treated rats had mean thigmotaxis (wall-following behavior that delays maze solving) values lower than those of aged vehicle-treated rats, and similar to that of young vehicle-treated rats. Jones et al. (SfN 2018) poster presentation