IW-6463

The Brain Penetrant Soluble Guanylate Cyclase Stimulator IWP-247 Improved Thigmotaxis and Increased Hippocampal N-acetylaspartate (NAA) Concentrations in Aged Rats

Society for Neuroscience Annual Meeting (2018)

Juli E. Jones, Christopher J. Winrow, Susana S. Correia, Sarah Jacobson, Robert Hodgson, Jukka Puolivali, Kimmo Lehtimäki, Andrew Carvalho, Peter Germano, Jenny V. Tobin, Kim Tang, Rajesh R. Iyengar, Mark G. Currie and John R. Hadcock

This research describes the effects of IW-6463, a central nervous system-penetrant sGC stimulator, on neurometabolites and learning in aged rats.

IW-6463 improved learning and memory in aged rats

Healthy aged male rats were administered IW-6463 (10 mg/kg, oral) daily during Morris Water Maze training. On days 4 and 5, IW-6463-treated rats had mean thigmotaxis (wall-following behavior that delays maze solving) values lower than those of aged vehicle-treated rats, and similar to that of young vehicle-treated rats. Jones et al. (SfN 2018) poster presentation

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